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Evolution: It’s all in how you splice it (MIT)
When genes were first discovered, the canonical view was that each gene
encodes a unique protein. However, biologists later found that segments of
genes can be combined in different ways, giving rise to many different
This phenomenon, known as alternative RNA splicing, often alters the outputs
of signaling networks in different tissues and may contribute
disproportionately to differences between species, according to a new study
from MIT biologists.
After analyzing vast amounts of genetic data, the researchers found that the
same genes are expressed in the same tissue types, such as liver or heart,
across mammalian species. However, alternative splicing patterns — which
determine the segments of those genes included or excluded — vary from species
“The core things that make a heart a heart are mostly determined by a heart-
specific gene expression signature. But the core things that make a mouse a
mouse may disproportionately derive from splicing patterns that differ from
those of rats or other mammals” says Chris Burge, an MIT professor of biology
and biological engineering, and senior author of a paper on the findings in
the Dec. 20 online edition of _Science_.
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